解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Atrial fibrillation (AF) is considered a predictor for severe stroke and poor outcome. The aim was to evaluate whether AF is associated with poor outcome in acute ischemic stroke (IS) patients treated with intravenous thrombolysis (IVT). In a retrospective study, 157 consecutive IS patients (98 males, mean age 67.3 +/...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-010-5452-4
更新日期:2010-06-01 00:00:00
abstract::The type and frequency of neurological manifestations of Behçet's disease (BD) vary with ethnicity. We analyzed the neurological manifestations of BD in Japanese patients. All patients undergoing treatment at one of the two Yokohama City University hospitals from July 1991 to December 2007 and who fulfilled the Japane...
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-010-5454-2
更新日期:2010-06-01 00:00:00
abstract::Acquired copper deficiency has been recognised as a rare cause of anaemia and neutropenia for over half a century. Copper deficiency myelopathy (CDM) was only described within the last decade, and represents a treatable cause of non-compressive myelopathy which closely mimics subacute combined degeneration due to vita...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-010-5511-x
更新日期:2010-06-01 00:00:00
abstract::We wanted to determine the neurocognitive profile of adult patients with moyamoya disease prior to neurosurgical intervention. The experience of three United States medical centers, Columbia University, University of Illinois at Chicago, and the University of Texas Southwestern Medical Center at Dallas, were combined....
journal_title:Journal of neurology
pub_type: 杂志文章,多中心研究
doi:10.1007/s00415-009-5424-8
更新日期:2010-05-01 00:00:00
abstract::Mitochondrial diseases are due to impairment of the mitochondrial respiratory chain. A plausible pathogenic mechanism leading to cellular dysfunction and phenotypic expression is oxidative stress, but there are surprisingly few clinical studies on this subject. Glutathione (GSH) deficiency has been reported in mitocho...
journal_title:Journal of neurology
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00415-009-5409-7
更新日期:2010-05-01 00:00:00
abstract::Recognition of multiple sclerosis (MS) attacks relies mostly on clinical assessment. However, their definition based on McDonald criteria refers mostly to timing and when dealing with clinical features is rather ambiguous: "...of the kind seen in multiple sclerosis." This is heightened in clinically isolated syndromes...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5403-0
更新日期:2010-05-01 00:00:00
abstract::Hereditary peripheral neuropathies present a group of clinically and genetically heterogeneous entities. All known forms, including the various forms of Charcot-Marie-Tooth disease (CMT) are characterized as Mendelian traits and over 35 genes have been identified thus far. The mutational mechanism of the most common C...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5401-2
更新日期:2010-05-01 00:00:00
abstract::We review the neuronal antibodies described in CNS disorders in order to clarify their diagnostic value, emphasize potentials pitfalls and limitations in the diagnosis of paraneoplastic neurological syndromes (PNS), and examine the current evidence for a possible pathogenic role. We propose to classify the neuronal an...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-009-5431-9
更新日期:2010-04-01 00:00:00
abstract::Tibial muscular dystrophy (TMD) or Udd myopathy is an autosomal dominant distal myopathy with late onset, at first described in the Finnish population. We report here the first Italian cases of TTN mutated titinopathy. The proband, a 60 year-old female, had the first muscular signs at the age of 59 years, with difficu...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5372-3
更新日期:2010-04-01 00:00:00
abstract::This study aimed at identifying gender-specific differences in stroke knowledge, stroke risk perception and the educational effects of a multimodal educational intervention. We performed computer-assisted telephone surveys among an average sample of 500 members of the general public (44.0% male, 56.0% female), before ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5326-9
更新日期:2010-03-01 00:00:00
abstract::In idiopathic rapid eye movement sleep behaviour disorder (RBD), an association with visuoperceptive disorders has been described. However, such an association has not been clearly established in RBD secondary to Parkinson's disease (PD). We compared visuoperceptive function in four groups of non-demented patients (pa...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5328-7
更新日期:2010-03-01 00:00:00
abstract::Optic neuritis usually presents with rapid and gradual loss of vision that is either complete or incomplete, and typically associated with retro-orbital pain. To our knowledge there have been no documented reports of optic neuritis presenting with multiple episodes of amaurosis fugax, the sudden and transient loss of ...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5302-4
更新日期:2009-12-01 00:00:00
abstract::The mechanism underlying the motor fluctuations that develop after long-term L-dopa therapy is not fully known. It has been speculated that malabsorption of L-dopa from the small intestine occurs. It was reported that gastric retention in Parkinson's disease (PD) patients with motor fluctuations is increased as compar...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5220-5
更新日期:2009-12-01 00:00:00
abstract::Multiple system atrophy (MSA) is a rare late onset neurodegenerative disorder which presents with autonomic failure and a complicated motor syndrome including atypical parkinsonism, ataxia and pyramidal signs. MSA is a glial alpha-synucleinopathy with rapid progression and currently poor therapeutic management. This p...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-009-5173-8
更新日期:2009-11-01 00:00:00
abstract::The spinocerebellar ataxias (SCAs) with autosomal dominant inheritance are a clinically and genetically heterogeneous group of neurological disorders with overlapping as well as highly variable phenotypes primarily affecting the cerebellum. To date, 28 different loci have been identified. Nine SCAs are caused by repea...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5209-0
更新日期:2009-11-01 00:00:00
abstract::This article describes the clinical features of anterior semicircular canal benign paroxysmal positional vertigo (AC-BPPV) and a new therapeutic maneuver for its management. Our study was a retrospective review of cases from an ambulatory tertiary referral center. Thirteen patients afflicted with positional paroxysmal...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5208-1
更新日期:2009-11-01 00:00:00
abstract::We report a rare association of spinocerebellar ataxia and motor neuron disease (MND) in a woman with genetically confirmed SCA2 who subsequently developed a rapidly progressive and fatal form of MND. Considering the rarity of these two neurological conditions, it is interesting to note that the concomitant occurrence...
journal_title:Journal of neurology
pub_type: 信件,评审
doi:10.1007/s00415-009-5237-9
更新日期:2009-11-01 00:00:00
abstract::We report the case of a 17.5-year old girl with generalized myasthenia gravis (MG). When she was 13, she started to complain of episodic diplopia, ptosis and mild fatigability of upper and lower extremity muscles. She was diagnosed with MG 3 years later, after exacerbation of her limb muscle weakness. Acetylcholine re...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5215-2
更新日期:2009-10-01 00:00:00
abstract::Although seizures in brain tumor patients are common, the knowledge on optimal anti-seizure therapy in this patient group is limited. An observational study was carried out using a database of all patients from the neuro-oncology service during the period 2000-2005, with data on seizure characteristics, therapy with A...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5156-9
更新日期:2009-09-01 00:00:00
abstract::We report on a 14-year-old boy with congenital isolated hemifacial hyperplasia. Hemifacial hypertrophy most likely represents a minor form of congenital hemihypertrophy. MRI of the soft tissue is particularly suitable to support the diagnosis and reveal associated bony asymmetries. ...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5148-9
更新日期:2009-09-01 00:00:00
abstract::This paper summarizes the methods we devised for the treatment of psychosis, orthostatic hypotension, and mood disorders among the various non-motor complications of Parkinson's disease. Psychosis may not manifest when a patient believes in his/her delusions. If left untreated over a prolonged period, however, the del...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-009-5245-9
更新日期:2009-08-01 00:00:00
abstract::There is still uncertainty regarding risk factors for cancer occurrence in patients with myasthenia gravis (MG). The objective of this study is to determine the prevalence of extrathymic neoplasms in patients with MG and the factors associated with tumor occurrence. The archives of four tertiary MG centers were consul...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5091-9
更新日期:2009-08-01 00:00:00
abstract::Leukocyte recruitment and inflammatory response play an important patho-physiologic role after cerebral ischemia. This study aimed to evaluate whether leukocyte adhesion molecules can predict clinical outcome in patients after ischemic stroke. We prospectively examined serial changes in p-selectin glycoprotein ligand-...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5117-3
更新日期:2009-08-01 00:00:00
abstract::Deep brain stimulation of the subthalamic nucleus (STN) is an effective treatment modality for motor symptoms of advanced Parkinson's disease. Recent studies focus on exploring its possible effects on cognition and behavior. We present a case with acute cognitive dysfunction due to misalignment of the electrodes to th...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5103-9
更新日期:2009-08-01 00:00:00
abstract::Rapid-eye-movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by complex motor activity associated with dreaming during REM sleep. RBD may be idiopathic or associated with various neurological diseases involving the brainstem. The association of RBD and limbic system impairment was unclear. We r...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5067-9
更新日期:2009-07-01 00:00:00
abstract::Carbon monoxide (CO) intoxication leads to acute and chronic neurological deficits, but little is known about the specific noxious mechanisms. (1)H magnetic resonance spectroscopy (MRS) may allow insight into the pathophysiology of CO poisoning by monitoring neurochemical disturbances, yet only limited information is ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-5057-y
更新日期:2009-06-01 00:00:00
abstract::Bilateral paramedian thalamic infarctions are usually associated with impaired consciousness, oculomotor disturbances and neuropsychological changes. A 44-year-old healthy woman presented with amaurosis fugax of the right eye immediately after a Valsalva maneuver. Neurological examination, in particular visual acuity,...
journal_title:Journal of neurology
pub_type: 信件
doi:10.1007/s00415-009-5030-9
更新日期:2009-06-01 00:00:00
abstract::Infectious agents have been proposed as potential causes of Alzheimer's disease (AD). Recently, we documented a high prevalence of Helicobacter pylori (Hp) infection in patients with AD. We aim to access the effect of Hp eradication on the AD cognitive (MMSE: Mini Mental State Examination and CAMCOG: Cambridge Cogniti...
journal_title:Journal of neurology
pub_type: 临床试验,杂志文章
doi:10.1007/s00415-009-5011-z
更新日期:2009-05-01 00:00:00
abstract::Knowledge of restless legs syndrome (RLS) has greatly increased in recent years due to the many advances that have been made in diagnosis, management and genetics. Tools have been developed that facilitate the diagnosis and treatment of RLS, in particular the essential diagnostic criteria for RLS have been refined, se...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-0134-9
更新日期:2009-04-01 00:00:00
abstract::Vertigo is frequently associated with migraine, and sometimes it is the cardinal symptom. This type of migraine is called "vestibular migraine", "migrainous vertigo", or "migraine-associated vertigo". Earlier findings on effective prophylactic medication for such migraine attacks and their clinical features are few an...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-0111-3
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Delayed ischaemic neurological deficit (DID) following subarachnoid haemorrhage from aneurysm rupture (aSAH) is a serious complication and a major cause of mortality and morbidity. No empirical estimates of resource use and costs of patients with delayed ischaemic deficit compared to those without have been ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-0034-z
更新日期:2009-03-01 00:00:00
abstract::Several reports in the literature describe the effects of low-dose (5 mg/kg/day) idebenone in significantly reducing cardiac hypertrophy in patients with Friedreich ataxia. However, the effects of idebenone on neurological function have not been reliably determined in these studies; when neurological parameters were r...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-009-1008-x
更新日期:2009-03-01 00:00:00
abstract:INTRODUCTION:Two population-based studies of neuromyelitis optica (NMO) in non-white populations provided prevalence rates of 0.32 and 3.1 per 100,000 population. OBJECTIVE:To estimate NMO prevalence in the multiethnic Cuban population by nation-wide case ascertainment. METHODS:The study was conducted from October 1,...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-009-0009-0
更新日期:2009-01-01 00:00:00
abstract::Applying microarray technology to identify new diagnostic and prognostic markers in peripheral blood cells (PBC) after therapeutic intervention opens great perspectives regarding patient subclassification. Three recombinant products of the pleiotropic agent interferon beta (rIFN-beta) are available for disease modifyi...
journal_title:Journal of neurology
pub_type: 杂志文章,评审
doi:10.1007/s00415-008-6010-1
更新日期:2008-12-01 00:00:00
abstract::We discuss two cases receiving different anti-tumornecrosis-factor alpha antagonists (anti-TNF-alpha); one for psoriatic arthritis (PA) and the other for ankylosing spondylitis (AS). Due to neurological symptoms cerebral magnetic resonance imaging (MRI) was performed and cerebral lesions were detected. Our interpretat...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-6020-z
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To characterize the progression of the cognitive involvement in patients affected by myotonic dystrophy type 1 (DM1) by a longitudinal neuropsychological follow-up study. METHODS:In a previous study we documented an ageing-related decline of frontal and temporal cognitive functions in juvenile/adult forms of...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0017-5
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To establish differences in basal ganglia and thalamic volume between preclinical carriers and non-carriers of the Huntington's disease (HD) gene and to link the volume to motor, cognitive and behavioural characteristics in carriers. METHODS:Sixteen HD gene carriers without overt clinical motor signs and 14 ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0050-4
更新日期:2008-11-01 00:00:00
abstract::In order to learn more on the occurrence of pains and motor deficit in severe diabetic polyneuropathy we reviewed the data of a series of 30 diabetic patients with an uncommonly severe length-dependent diabetic polyneuropathy (LDDP). Extensive sensory loss predominated with pains and temperature sensations and affecte...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0999-z
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The number of neurological second opinions (SO) and tertiary referrals (TR) is increasing. The main purpose of this study was to assess whether a day-care admission made a meaningful contribution to standard neurological outpatient care, for a wide range of second opinions and tertiary referral...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0019-3
更新日期:2008-11-01 00:00:00
abstract::Sudden death has been reported in patients with multiple system atrophy (MSA), although the frequency of this event has not been well delineated. We investigated the frequency and potential causes of sudden death in patients with MSA. During the 5-year observation period, 10 of 45 patients with probable MSA died. The ...
journal_title:Journal of neurology
pub_type: 杂志文章
doi:10.1007/s00415-008-0941-4
更新日期:2008-10-01 00:00:00